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KMID : 0829220090330050245
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Korean Journal of Oral and Maxillofacial Pathology
2009 Volume.33 No. 5 p.245 ~ p.250
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Yoon Jung-Hoon
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Abstract
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Amino acid transporters play an important role in supplying organic nutrient to cells. The expression profile of L-type amino acid transporter 1 (LAT1) and its subunit 4F2 heavy chain (4F2hc) on different differentiation stages in 4-NQO induced rat tongue carcinogenesis was examined using immunohistochemical analysis. The gradually increasing LAT1 and 4F2hc expression detected during the multistep progressive change shows that the protein may have an important role in the multistep tongue carcinogenesis. Conclusively, LAT1 and 4F2hc can be a useful biomarker for a better understanding of multistep tongue carcinogenesis, while the specific inhibition of LAT1 and 4F2hc would be a new rationale for suppressing tumor cell growth in tongue cancer.
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KEYWORD
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LAT1, 4F2hc, Tongue carcinogenesis, Biomarker
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